Defactinib

CAT: 0498-bs-83039C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-83039C-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM) .1 It is active in vivo (EC50 = 26nM) . FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
HY-12289-01Defactinib
MBS3846425-01Defactinib hydrochloride
HY-12289A-01Defactinib (hydrochloride)
A21958-200Defactinib 200mg
206742Defactinib HCl
A21958-25Defactinib 25mg
A21958-100Defactinib 100mg
HY-12289R-01Defactinib (Standard)
HY-12289SDefactinib-d6

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