Defactinib analogue-1

Defactinib analogue-1

• CAS Number: 2296719-34-9
• UNSPSC Description: Defactinib analogue-1 (Compound 7) is a ligand for target protein Fak, that can be used for synthesis of PROTAC FAK degrader 1 (HY-119932)[1].
• Target Antigen: FAK; Ligands for Target Protein for PROTAC
• Type: Reference compound
• Related Pathways: PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/defactinib-analogue-1.html
• Purity: 99.33
• Smiles: CS(=O)(N(C)C1=CC=CC(CNC2=NC(NC3=CC=C(O)C=C3)=NC=C2C(F)(F)F)=C1)=O
• Molecular Weight: 467.47
• References & Citations: [1]Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported