NVP-231

CAT: 0498-bs-82993C-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-82993C-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Reversible inhibitor of ceramide kinase (IC50 = 12 nM) .1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa. NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest.2 It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells3 as well as MDA-MB-231 breast cancer cells4.

Conjugation

Unconjugated

Buffer

White solid

Storage Conditions

-20°C

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Alternative Products

Catalog	Name
B1235-50	NVP 231
B2225-25	NVP-231

NVP-231

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