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FSC-231

CAT: 0498-bs-82225C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82225C-01Size:5 mg
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Background
The first small-molecule inhibitor of the PDZ domain in protein interacting with C kinase 1 (PICK1) . Binds to PICK1 PDZ domain with affinity similar to that of the endogenous peptide ligands (Ki~10.1 µM) . Does not bind to PDZ domains of postsynaptic density protein 95 (PSD-95) nor glutamate receptor interacting protein 1 (GRIP1) . Pretreatment of cultured hippocampal neurons inhibits coimmunoprecipitation of the AMPA receptor GluR2 subunit with PICK1. FSC231 accelerated recycling of fluorophore-tagged GluR2 in hippocampal neurons after internalization in response to NMDA receptor activation. Blocks the expression of both long-term depression and long-term potentiation.1,2 Attenuates cocaine seeking in a rodent model.3 Blocks PICK1-induced anti-inflammatory effect in acute liver injury.4
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
RT

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