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Enasidenib

CAT: 0498-bs-82974C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82974C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Enasidenib is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2) .1 It suppressed the production of the oncometabolite (R) -2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2 Recently approved for clinical use by the FDA.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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A15808-10Enasidenib 10mg
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