Enasidenib-d6

• Description :

  Enasidenib-d6 (AG-221-d6) is the deuterium labeled Enasidenib (HY-18690) [1]. Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively[2].

• Product Name Alternative :

  AG-221-d6

• UNSPSC :

  12352005

• Target :

  Isocitrate Dehydrogenase (IDH) ; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Others

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])([2H])C(C([2H])([2H])[2H])(O)CNC1=NC(NC2=CC=NC(C(F)(F)F)=C2)=NC(C3=CC=CC(C(F)(F)F)=N3)=N1

• Molecular Formula :

  C19H11D6F6N7O

• Molecular Weight :

  479.41

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [2095569-76-7]