ABX-1431

• Background:

  Potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhibitor of monoacylglycerol lipase (MAGL) .1 Active in a rat formalin pain test at 3mg/kg. Orally bioavailable and CNS penetrant.

• Conjugation:

  Unconjugated

• Buffer:

  White solid

• Storage Conditions:

  -20°C