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Ko-143

CAT: 0498-bs-82051C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82051C-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP/ABCG2) 1. Reverses resistance of MTX and topotecan at 25 nM in human and mouse cell lines.1 Also inhibits ABCB1 and ABCC1 at concentrations >1 μM.2 Restores the sensitivity of triple negative breast cancer cells to photodynamic therapy.3 Prevents the export of the FAAH inhibitor URB937 from the CNS.4 Forces prostate stem cells to undergo and AR-modulated differentiation to an androgen deprivation therapy-sensitive luminal phenotype.5 Active in vivo.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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TQ0186-01Ko 143
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A11475-50Ko-143 50mg
A11475-2Ko-143 2mg
A11475-5Ko-143 5mg
A11475-25Ko-143 25mg
A11475-100Ko-143 100mg
HY-10010RKo 143 (Standard)
TBI1074-25MGKo-143, BCRP inhibitor

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