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Indoximod

CAT: 0498-bs-82928C-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82928C-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.4
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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