MF-438

CAT: 0498-bs-82920C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82920C-01Size:5 mg
Selected
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg) .1 Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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