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Streptonigrin

CAT: 0498-bs-82684CSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82684CSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Streptonigrin promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4
Conjugation
Unconjugated
Buffer
Black solid
Storage Conditions
-20°C

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