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Vatalanib 2HCl

CAT: 0498-bs-82428C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82428C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM) 1. Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 µM) . Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 µM) . Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.
Conjugation
Unconjugated
Buffer
White or off-white solid
Storage Conditions
-20°C

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GTR19168142-01Vatalanib 2HCl
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