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Erlotinib · HCl

CAT: 0498-bs-82407C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82407C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM) 1. Potent inhibitor of mutant JAK2-V617F2. Weaker inhibitor of ErbB-2 kinase (Ki = 1 μM) ErbB-4 kinase (Ki = 1.5 μM) 3. HDAC inhibitors sensitize for erlotinib activity in EGFR-mutated and wildtype non-small cell lung cancer (NSCLC) cells4. A clinically effective agent for NSCLC5.
Conjugation
Unconjugated
Buffer
White or off-white solid
Storage Conditions
-20°C

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