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GSK-J4

CAT: 0498-bs-82219C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82219C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release) . Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.
Conjugation
Unconjugated
Buffer
Yellow waxy solid
Storage Conditions
-20°C

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