GSK-J4

• Background:

  Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release) . Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.

• Conjugation:

  Unconjugated

• Buffer:

  Yellow waxy solid

• Storage Conditions:

  -20°C