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PIT-1

CAT: 0498-bs-82123C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82123C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM) . Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM) 1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
Conjugation
Unconjugated
Buffer
Grey solid
Storage Conditions
RT

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