PIT-1

• Background:

  PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM) . Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM) 1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.

• Conjugation:

  Unconjugated

• Buffer:

  Grey solid

• Storage Conditions:

  RT