7,8-Dihydroxyflavone

• Background:

  A selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity.1,2 Significantly improves motor deficits, ameliorates brain atrophy and extends survival in the well-characterized N171-82Q Huntington’s disease mouse model.3 Post-traumatic brain injury-treatment promotes neurogenesis in the hippocampus in a mouse model.4 Improves motor performance and motor neuronal survival in an ALS mouse model.5

• Conjugation:

  Unconjugated

• Buffer:

  Yellow or tan solid

• Storage Conditions:

  -20°C