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AG-490

CAT: 0498-bs-82062C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82062C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4.
Conjugation
Unconjugated
Buffer
Tan solid
Storage Conditions
-20°C

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Alternative Products

CatalogName
200121AG-490
S1509AG 490

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