GW-5074

• Background:

  Potent inhibitor of cRAF1 kinase (IC50 = 9 nM) . Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects In vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.

• Conjugation:

  Unconjugated

• Buffer:

  Dark orange solid MP = 267-268°C

• Storage Conditions:

  -20°C