SERCA2a activator 1

SERCA2a activator 1

• CAS Number: 2139330-34-8
• UNSPSC Description: SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure[1].
• Target Antigen: Calcium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/serca2a-activator-1.html
• Purity: 99.71
• Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: O=C(C1=CC(C(C=C2CC3=CC=CC=C3)=CN(CCCC)C2=O)=NC=C1)NS(=O)(C4=CC=C5C=CC=CC5=C4)=O
• Molecular Weight: 551.66
• References & Citations: [1]Kaneko M, et al. A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban. Eur J Pharmacol. 2017 Nov 5;814:1-8.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported