HIF-1α-IN-4

HIF-1α-IN-4

• CAS Number: 2826221-23-0
• UNSPSC Description: HIF-1α-IN-4 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-4 can be used in the research of cancer[1].
• Target Antigen: HIF/HIF Prolyl-Hydroxylase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hif-1α-in-4.html
• Solubility: DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(C1=NOC2=CC=CC=C12)NC3=CC=C(C(C)=O)C=C3
• Molecular Weight: 280.28
• References & Citations: [1]Zian Xue, et al. Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF)-1α Inhibitors. ACS Med. Chem. Lett. 2022.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported