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CD20 Antibody

CAT: 0800-V2397IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
CAT#:0800-V2397IHC-7MLSize:7 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antibody recognizes a protein of 33-37kDa, identified as CD20. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This antibody can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, Bcell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. It is expressed by pre Bcells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as a calcium channel involved in B-cell activation and cell cycle progression.
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P11836
Host
Mouse
Reactivity
Human
Immunogen
Human tonsil B cells were used as the immunogen for this CD20 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
SPM494
Applications
IHC-P
Format
Bioreactor concentrate
Buffer
1X PBS, pH 7.4
Limitations
This CD20 antibody is available for research use only.
Storage Conditions
CD20 antibody with azide can be stored at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Predominantly cell surface with some cytoplasmic
Image Legend
IHC testing of CD20 antibody and FFPE human lymphoma tissue (clone SPM494) .

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