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CALB1 Antibody / Calbindin

CAT: 0800-V5810-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V5810-20UGSize:20 µg
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Description
The family of EF-hand type Ca2+-binding proteins includes Calbindin D28K, Calbindin D9K, S-100 (also designated oncomodulin) . Calbindin D28K, also known as calbindin, CALB1, D-28K or vitamin D-dependent calcium-binding protein, is a 261-amino acid protein with 6 EF-hand domains, 4 of which are active calcium-binding domains. Expressed in brain, ovary, uterus, testis, pancreas, liver, kidney and intestine, Calbindin D28K acts as a calcium-buffering agent and alters the activity of the plasma membrane ATPase. In neuronal cells, Calbindin D28K modulates calcium channel activity, calcium transients and intrinsic neuronal firing activity. Also, Calbindin D28K has been implicated to play a role in apoptosis and microtubule function.
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P05937
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 7-96 from human Calbindin protein was used as the immunogen for the CALB1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
KR6
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Limitations
This CALB1 antibody is available for research use only.
Storage Conditions
Aliquot the CALB1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CALB1 antibody should be determined by the researcher.
Location
Nucleus, Cytoplasm
Image Legend
IHC staining of FFPE human tonsil tissue with CALB1 antibody (clone KR6) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P05937

Calbindin

CALB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05937
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CALB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R696, B7Z9J4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingVitamin D

Domain

Repeat

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