Products for Research Use Only

Calbindin Antibody / CALB1

CAT: 0013-GTR18575029Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18575029Size:100 µg
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Description
The family of EF-hand type Ca2+-binding proteins includes Calbindin D28K, Calbindin D9K, S-100 (also designated oncomodulin) . Calbindin D28K, also known as calbindin, CALB1, D-28K or vitamin D-dependent calcium-binding protein, is a 261-amino acid protein with 6 EF-hand domains, 4 of which are active calcium-binding domains. Expressed in brain, ovary, uterus, testis, pancreas, liver, kidney and intestine, Calbindin D28K acts as a calcium-buffering agent and alters the activity of the plasma membrane ATPase. In neuronal cells, Calbindin D28K modulates calcium channel activity, calcium transients and intrinsic neuronal firing activity. Also, Calbindin D28K has been implicated to play a role in apoptosis and microtubule function.
UniProt
P05937
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 7-96) was used as the immunogen for this Calbindin antibody.
Clonality
Monoclonal
Clone
CALB1/2782
Conjugation
Unconjugated
Purification
Protein G affinity chromatography
Dilution
ELISA (order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Calbindin antibody should be determined by the researcher.
Tested Applications
ELISA, IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

UniProtKB · P05937

Calbindin

CALB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05937
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CALB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R696, B7Z9J4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingVitamin D

Domain

Repeat