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Anti-CDK5 Antibody

CAT: 0942-308-CDK5tSize: 25 µLDry Ice: NoHazardous: No
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CAT#:0942-308-CDK5tSize:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The neuronal protein kinase, Cdk5 has been implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis (Kansy J et al., 2004), the presynaptic vesicle cycle (Nguyen, C. & Bibb, JA 2003), neurotransmitter receptor trafficking and dopamine neurotransmission (Bibb, JA et al. 1999) . At the same time Cdk5 has been implicated in a plethora of neurological and neuropsychiatric disorders including Alzheimer’s, Parkinson’s, Huntington’s, epilepsy, schizophrenia, and drug addiction. Detection of Cdk5 in normal samples as well as tissue undergoing neurodegeneration may advance studies in these areas. Moreover, this antibody may allow more accurate postmortem evaluations of Cdk5 protein expression, and thus serve as a valuable new reagent for neuropathology.
Description
Our Anti-CDK5 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat CDK5 and is Protein G purified. It is great for use in WB, IHC.
Synonyms
Cdk 5 antibody, Cdk5 antibody, CDK5_HUMAN antibody, Cell division protein kinase 5 antibody, Crk6 antibody, Cyclin dependent kinase 5 antibody, Cyclin-dependent kinase 5 antibody, Protein kinase CDK5 splicing antibody, PSSALRE antibody, Serine threonine protein kinase PSSALRE antibody, Serine/threonine-protein kinase PSSALRE antibody, Tau protein kinase II catalytic subunit antibody, TPKII catalytic subunit antibody
Other Statements
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Gene Name
CDK5
NCBI Gene ID
140908
UniProt
Q03114
Host
Mouse
Reactivity
Human, Mouse, and Rat
Immunogen
Purified rat Cdk5.
Immunogen Type
Rat
Target
CDK5
Clonality
Monoclonal
Clone
1H3
Conjugation
Unconjugated
Applications
ELISA, WB, IHC
Concentration
1 mg/ml
Format
Protein G Purified
Form
Liquid
Buffer
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Molecular Weight
28
Shipping Conditions
Blue Ice
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
IHC Dilution
1:50-1:1000
WB Dilution
1:1000
Specificity
Specific for endogenous levels of the ~28 kDa Cdk5 protein. Shows no cross reactivity with the Cdk5 cofactor p35 or its degradation product p25.
Formulation
Protein G purified culture supernatant.
Quality Control
Western blots performed on each lot.
Isotype
IgG1

UniProtKB · Q03114

Cyclin-dependent kinase 5

CDK5_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q03114
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Cdk5
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
—
Protein keywords

PTM

AcetylationPhosphoprotein

Biological process

ApoptosisBiological rhythmsCell cycleCell divisionNeurogenesis

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCell projectionCytoplasmMembraneNucleusSynapse

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

Disease

Neurodegeneration

Technical term

Reference proteome

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