DOCK 2 Rabbit Polyclonal Antibody

CAT: 1444-APRab10101-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab10101-01Size:20 µL
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Background
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016], domain:The DHR-2 domain may mediate the GEF activity., function:Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2 small GTPases, probably by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2., similarity:Belongs to the DOCK family., similarity:Contains 1 DHR-1 (CZH-1) domain., similarity:Contains 1 DHR-2 (CZH-2) domain., similarity:Contains 1 SH3 domain., subcellular location:Colocalizes with F-actin., subunit:Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z., tissue specificity:Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.
Product Name Alternative
DOCK2; KIAA0209; Dedicator of cytokinesis protein 2
Gene Name
DOCK2
Gene ID
1794
Swiss Prot
Q92608
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF, ELISA
Field of Research
Chemokine; Fc gamma R-mediated phagocytosis
Purification
Affinity purification
Dilution
IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:20000-1:40000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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