Products for Research Use Only

Recombinant Human CD98 (N-mFc)

CAT: 1444-PHH2418-01Size: 10 µgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:1444-PHH2418-01Size:10 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis, invasiveness, and proliferation in addition to promoting malignant transformation of cells. Fibrotic progression in the liver could be linked to the activation of integrin αvβ1 via CD98. CD98’s role in T cell activation in which the TGF activation could also play a profibrotic role.
Product Name Alternative
4F2 cell-surface antigen heavy chain; 4F2hc; SLC3A2; Lymphocyte activation antigen 4F2 large subunit; Solute carrier family 3 member 2; MDU1; CD98
Accession Number
P08195
Host
Human cells
Endotoxin
<1 EU/µg as determined by LAL test.
Purity
Greater than 95% as determined by reducing SDS-PAGE
Form
Liquid
Molecular Weight
72.7 KDa
Shipping Conditions
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Formulation
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH7.4.
Construct
Recombinant Human 4F2 Cell-surface Antigen Heavy Chain is produced by our Mammalian expression system and the target gene encoding Arg206-Ala630 is expressed with a mFc tag at the N-terminus.
Species
Human