IPAG

CAT: 0804-HY-100985-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100985-01Size:5 mg
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Description
IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3[1]. IPAG induces apoptosis[2].
CAS Number
[193527-91-2]
UNSPSC
12352005
Hazard Statement
H410
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ipag.html
Purity
99.84
Solubility
DMSO : 8.33 mg/mL (ultrasonic; adjust pH to 3 with 1M HCl; heat to 60°C)
Smiles
N=C(NC1=CC=C(I)C=C1)NC2[C@H]3C[C@H](C4)C[C@@H]2C[C@H]4C3
Molecular Formula
C17H22IN3
Molecular Weight
395.28
Precautions
P273-P391-P501
References & Citations
[1]James M Brimson, et al. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Sci Rep. 2020 Jun 8;10 (1) :9251.|[2]Halley M Oyer, et al.Small-Molecule Modulators of Sigma1 and Sigma2/TMEM97 in the Context of Cancer: Foundational Concepts and Emerging Themes. Front Pharmacol. 2019 Oct 21;10:1141.|[3]Felix J Kim, et al. Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun. 2012 Sep 21;426 (2) :177-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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