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(Glu2) -TRH

CAT: 0804-HY-P3960-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P3960-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Glu2) -TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2) -TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2) -TRH is not metabolized by thyroliberinase. (Glu2) -TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].
CAS Number
85541-78-2
UNSPSC
12352209
Target
Endogenous Metabolite; Thyroid Hormone Receptor
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/glu2-trh.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1CCC(N1)=O)N[C@@H](CCC(O)=O)C(N2[C@@H](CCC2)C(N)=O)=O
Molecular Formula
C15H22N4O6
Molecular Weight
354.36
References & Citations
[1]Vien Nguyen, et al. [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82 (1-2) :83-6.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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