(Glu2) -TRH

• Target :

  Thyroid hormone receptor (THR) |||Endogenous Metabolite

• Related Pathways :

  Metabolism|||Endocrinology/Hormones

• Bioactivity :

  (Glu2) -TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), acts as a negative modulator of TRH's cholinergic effect in the mouse brain, significantly reducing TRH-induced release of extracellular acetylcholine in the hippocampus. Resistant to metabolism by thyroliberinase, (Glu2) -TRH exhibits neuroprotective, antidepressant, and anticonvulsant properties in the CNS [1].

• Smiles :

  NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)N1

• Molecular Formula :

  C15H22N4O6

• Molecular Weight :

  354.36

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  85541-78-2