Products for Research Use Only
RegisterLogin

Ceritinib (Standard)

CAT: 0804-HY-15656R-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15656R-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ceritinib (Standard) is the analytical standard of Ceritinib. This product is intended for research and analytical applications. Ceritinib (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib (LDK378) also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib (LDK378) shows great antitumor potency[1][2].
CAS Number
1032900-25-6
Product Name Alternative
LDK378 (Standard)
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; IGF-1R; Insulin Receptor; Reference Standards
Type
Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ceritinib-standard.html
Purity
99.72
Smiles
CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3
Molecular Formula
C28H36ClN5O3S
Molecular Weight
558.14
References & Citations
[1]Marsilje TH, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2- (2-isopropoxy-5-methyl-4- (piperidin-4-yl) phenyl) -N4- (2- (isopropylsulfonyl) phenyl) pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013 Jul 25;56 (14) :5675-90.|[2]Chen J, et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J Med Chem. 2013 Jul 25;56 (14) :5673-4.|[3]Tucker ER, et al. Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma. Mol Oncol. 2017 Aug;11 (8) :996-1006.|[4]Rothschild SI. Ceritinib-a second-generation ALK inhibitor overcoming resistance in ALK-rearranged non-small celllung cancer. Transl Lung Cancer Res. 2014 Dec;3 (6) :379-81.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

Related Products

CatalogName
HY-15656AR-01Ceritinib dihydrochloride (Standard)
HY-I0875RCeritinib impurity 5 (Standard)
HY-15656-01Ceritinib
HY-15656SCeritinib-d7
HY-15656A-01Ceritinib dihydrochloride
HY-I0875-01Ceritinib impurity 5
HY-179418Ceritinib-platinum (IV) -4-phenylbutyrate
HY-P2274RArgifin (Standard)
HY-N9362REmodinanthrone (Standard)
HY-N7948RIsomaltotetraose (Standard)

Alternative Products

CatalogName
T1791-01Ceritinib
TRC-C367367-25MGCeritinib-d7
GTR19178095-01Ceritinib dihydrochloride
123125Ceritinib HCl
MBS576681LDK378(Ceritinib)
T10766-01Ceritinib D7

Popular Products