Ceritinib

• Target:

  ALK|||Serine Protease|||IGF-1R

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||Proteases/Proteasome

• Purity:

  >99.99%

• Bioactivity:

  Ceritinib (LDK378) is an ALK tyrosine kinase inhibitor (IC50=200 pM) with selective, ATP-competitive, and oral activity. Ceritinib also inhibits IGF-1R, InsR, and STK22D (IC50=8/7/23 nM) . Ceritinib has antitumor activity.

• Smiles:

  N (C1=C (OC (C) C) C=C (C (C) =C1) C2CCNCC2) C=3N=C (NC4=C (S (C (C) C) (=O) =O) C=CC=C4) C (Cl) =CN3

• Molecular Formula:

  C28H36ClN5O3S

• Molecular Weight:

  558.14

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1032900-25-6