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PMSF

CAT: 0804-HY-B0496-03Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0496-03Size:500 mg
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Description
PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates[1][2][3][4].
CAS Number
329-98-6
Product Name Alternative
Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride
UNSPSC
12352005
Hazard Statement
H225, H315, H319
Target
Cathepsin; Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pmsf.html
Purity
99.49
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL|Isopropyl alcohol : 60 mg/mL (ultrasonic)
Smiles
O=S(CC1=CC=CC=C1)(F)=O
Molecular Formula
C7H7FO2S
Molecular Weight
174.19
Precautions
H225, H315, H319
References & Citations
[1]Sekar, M.C. and B.D. Roufogalis, Differential effects of phenylmethanesulfonyl fluoride (PMSF) on carbachol and potassium stimulated phosphoinositide turnover and contraction in longitudinal smooth muscle of guinea pig ileum. Cell Calcium, 1984. 5 (3) : p.|[2]Guther, M.L., W.J. Masterson, and M.A. Ferguson, The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes. J Biol Chem, 1994. 269 (28) : p. 18694-701.|[3]Compton, D.R. and B.R. Martin, The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. J Pharmacol Exp Ther, 1997. 283 (3) : p. 1138-43.|[4]Asadi Akbarabadi E, et a. PMSF Attenuates Morphine Antinociceptive Tolerance and Dependence in Mice: Its Association with the Oxidative Stress Suppression. Iran J Pharm Res. 2021 Summer;20 (3) :300-309.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Phenylmethylsulfonyl Fluoride

Phenylmethanesulfonyl fluoride is an acyl fluoride with phenylmethanesulfonyl as the acyl group. It has a role as a serine proteinase inhibitor. It is functionally related to a phenylmethanesulfonic acid.

CAS Number329-98-6
PubChem CID4784
IUPAC Namephenylmethanesulfonyl fluoride
Molecular FormulaC7H7FO2S
Molecular Weight174.19
XLogP1.3
Topological Polar Surface Area42.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count11
Formal Charge0
Complexity199
SMILES
C1=CC=C(C=C1)CS(=O)(=O)F
InChI
InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChIKey
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Phenylmethylsulfonyl Fluoride
CAS: 329-98-6
CID: 4784
Formula: C7H7FO2S
MW: 174.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight174.19
XLogP31.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass174.01507880
Monoisotopic Mass174.01507880
Topological Polar Surface Area42.5 Ų
Heavy Atom Count11
Formal Charge0
Complexity199
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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