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PMSF

CAT: 0804-HY-B0496-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0496-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates[1][2][3][4].
CAS Number
329-98-6
Product Name Alternative
Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride
UNSPSC
12352005
Hazard Statement
H225, H315, H319
Target
Cathepsin; Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pmsf.html
Purity
99.49
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL|Isopropyl alcohol : 60 mg/mL (ultrasonic)
Smiles
O=S(CC1=CC=CC=C1)(F)=O
Molecular Formula
C7H7FO2S
Molecular Weight
174.19
Precautions
H225, H315, H319
References & Citations
[1]Sekar, M.C. and B.D. Roufogalis, Differential effects of phenylmethanesulfonyl fluoride (PMSF) on carbachol and potassium stimulated phosphoinositide turnover and contraction in longitudinal smooth muscle of guinea pig ileum. Cell Calcium, 1984. 5 (3) : p.|[2]Guther, M.L., W.J. Masterson, and M.A. Ferguson, The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes. J Biol Chem, 1994. 269 (28) : p. 18694-701.|[3]Compton, D.R. and B.R. Martin, The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. J Pharmacol Exp Ther, 1997. 283 (3) : p. 1138-43.|[4]Asadi Akbarabadi E, et a. PMSF Attenuates Morphine Antinociceptive Tolerance and Dependence in Mice: Its Association with the Oxidative Stress Suppression. Iran J Pharm Res. 2021 Summer;20 (3) :300-309.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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