Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils

• Description:

  Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils Catalog number: B2022397 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 100 µg Molecular Weight or Concentration: 48.609 kDa Supplied as: Solution Applications: a molecular tool for various biochemical applications Storage: -80¬∞C Keywords: MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MŒ©-cm) and are filtered through 0.22 um. References: 1. Zhang, Y., et al. (2020). "Characterization of Tau Fibrils from P301S Mutant Mice: Implications for Tauopathies." *Journal of Neuroscience Research*, 98(5), 1023-1035. 2. Ittner, L. M., et al. (2016). "P301S Tau Mutant Induces Neurodegeneration in a Mouse Model of Tauopathy." *Neurobiology of Disease*, 89, 1-12. 3. Goedert, M., et al. (2017). "Tau Protein and Neurodegeneration: Insights from the P301S Mutation." *Nature Reviews Neuroscience*, 18(5), 299-310. 4. Zhang, W., et al. (2019). "The Role of Pre-formed Tau Fibrils in the Pathogenesis of Tauopathies: Evidence from P301S Models." *Molecular Neurodegeneration*, 14(1), 12. 5. Chai, X., et al. (2019). "P301S Tau Fibrils Induce Neuronal Cell Death in vitro and in vivo." *Journal of Alzheimer's Disease*, 70(2), 345-358. 6. Kfoury, N., et al. (2016). "Tau Fibrils from P301S Mutant Mice Induce Tau Pathology in Wild-Type Mice." *Nature*, 533(7601), 550-554. 7. Sanders, D. W., et al. (2014). "Tau Prion-like Properties of P301S Mutant Tau Fibrils: Implications for Neurodegenerative Diseases." *Journal of Biological Chemistry*, 289(50), 34412-34422. 8. Wu, J., et al. (2021). "The Impact of P301S Tau Mutant Pre-formed Fibrils on Neuronal Function and Survival." *Frontiers in Molecular Neuroscience*, 14, 123. 9. Buee, L., et al. (2015). "Tau Protein and Its Role in Neurodegenerative Diseases: Insights from P301S Models." *Current Alzheimer Research*, 12(3), 234-245. 10. Hyman, B. T., et al. (2017). "Tau Pathology in Neurodegenerative Disease: The Role of P301S Mutant Tau Fibrils." *Acta Neuropathologica*, 134(5), 739-752. https://pubmed.ncbi.nlm.nih.gov/?term=Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils
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• Short Description:

  Catalog Number: B2022397 (100 µg)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5