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Huwentoxin IV

CAT: 1410-M30669Size: 1 EachDry Ice: NoHazardous: No
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CAT#:1410-M30669Size:1 Each
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Description
Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM) . Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.
CAS Number
526224-73-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
4106.79
Molecular Formula
C174H278N52O51S6
Notes
Research use only, not for human use.
Receptor
——

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