BML-278

• Description:

  BML-278 is a SIRT1 activator with an EC150 of 1 μM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development. BML-278 induces cell cycle arrest at the G1/S phase in primary human mesenchymal stromal cells, delaying senescence. It also reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  391.46

• Molecular Formula:

  C24H25NO4

• Notes:

  Research use only, not for human use.

• Receptor:

  Sirtuin | Histone Methyltransferase

• CAS Number:

  120533-76-8