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BML-278

CAT: 1410-M37061-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1410-M37061-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BML-278 is a SIRT1 activator with an EC150 of 1 μM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development. BML-278 induces cell cycle arrest at the G1/S phase in primary human mesenchymal stromal cells, delaying senescence. It also reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts.
CAS Number
120533-76-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
391.46
Molecular Formula
C24H25NO4
Notes
Research use only, not for human use.
Receptor
Sirtuin | Histone Methyltransferase

Chemical Information

Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate

4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester is a dihydropyridine.

CAS Number120533-76-8
PubChem CID10620479
IUPAC Namediethyl 1-benzyl-4-phenyl-4H-pyridine-3,5-dicarboxylate
Molecular FormulaC24H25NO4
Molecular Weight391.5
XLogP4.2
Topological Polar Surface Area55.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count29
Formal Charge0
Complexity591
SMILES
CCOC(=O)C1=CN(C=C(C1C2=CC=CC=C2)C(=O)OCC)CC3=CC=CC=C3
InChI
InChI=1S/C24H25NO4/c1-3-28-23(26)20-16-25(15-18-11-7-5-8-12-18)17-21(24(27)29-4-2)22(20)19-13-9-6-10-14-19/h5-14,16-17,22H,3-4,15H2,1-2H3
InChIKey
JOHFECBOWRGWJZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS: 120533-76-8
CID: 10620479
Formula: C24H25NO4
MW: 391.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight391.5
XLogP34.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass391.17835828
Monoisotopic Mass391.17835828
Topological Polar Surface Area55.8 Ų
Heavy Atom Count29
Formal Charge0
Complexity591
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BA4522-25BML-278
TBI1063-25MGBML-278, SIRT1 activator
abx076709-01Bml-278 SIRT1 activator
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