NX-2127

CAT: 1410-M36530-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M36530-01Size:1 g
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NX-2127 (ETX2514 Triethylamine) is an orally active BTK inhibitor that induces degradation of mutant BTKC481S in cells.NX-2127 has potent antiproliferative activity and inhibits the proliferation of BTKC481S mutant TMD8 cells.NX-2127 potently catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) at 25 nM and 54 nM, respectively. NX-2127 is associated with the immune system, stimulating T cell activation and increasing IL-2 production in primary human T cells.
CAS Number
2416131-46-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
719.83
Molecular Formula
C39H45N9O5
Notes
Research use only, not for human use.
Receptor
BTK

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