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Orphenadrine

CAT: 1410-M36262-01Size: 1 EachDry Ice: NoHazardous: No
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Description
Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagonist of central and peripheral muscarinic receptors. Attenuation is blocked by mutations in pore residues Y652 or F656. Orphenadrine has antispasmodic, analgesic, and anticholinergic activity and protects against glutamatergic neurotoxicity in vitro and in vivo.Orphenadrine has inhibitory effects on sodium channels and can be used in the treatment of Parkinson's disease.
CAS Number
83-98-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
269.38
Molecular Formula
C18H23NO
Notes
Research use only, not for human use.
Receptor
NMDAR | Sodium Channel | AChR

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