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SR-0813

CAT: 1410-M35189-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M35189-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9, with an IC50 of 25 nM and EC50 of 205 nM for the ENL YEATS domain, and an IC50 of 311 nM and EC50 of 76 nM (CETSA) for the AF9 YEATS domain. It shows over 100-fold lower affinity for MAP3K19 (Kd = 3.5 μM) compared to ENL YEATS (Kd = 30 nM) . SR-0813 can be utilized in acute leukemia research.
CAS Number
2597186-19-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
496.62
Molecular Formula
C25H32N6O3S
Notes
Research use only, not for human use.
Receptor
Epigenetic Reader Domain

Chemical Information

N-cyclobutyl-2-(3-((N-(2-(piperidin-1-yl)ethyl)sulfamoyl)amino)phenyl)imidazo[1,2-a]pyridine-6-carboxamide
CAS Number2597186-19-9
PubChem CID155885713
IUPAC NameN-cyclobutyl-2-[3-(2-piperidin-1-ylethylsulfamoylamino)phenyl]imidazo[1,2-a]pyridine-6-carboxamide
Molecular FormulaC25H32N6O3S
Molecular Weight496.6
XLogP3.2
Topological Polar Surface Area116
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Heavy Atom Count35
Formal Charge0
Complexity811
SMILES
C1CCN(CC1)CCNS(=O)(=O)NC2=CC=CC(=C2)C3=CN4C=C(C=CC4=N3)C(=O)NC5CCC5
InChI
InChI=1S/C25H32N6O3S/c32-25(27-21-7-5-8-21)20-10-11-24-28-23(18-31(24)17-20)19-6-4-9-22(16-19)29-35(33,34)26-12-15-30-13-2-1-3-14-30/h4,6,9-11,16-18,21,26,29H,1-3,5,7-8,12-15H2,(H,27,32)
InChIKey
GPMTWAPXRJMXCC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-cyclobutyl-2-(3-((N-(2-(piperidin-1-yl)ethyl)sulfamoyl)amino)phenyl)imidazo[1,2-a]pyridine-6-carboxamide
CAS: 2597186-19-9
CID: 155885713
Formula: C25H32N6O3S
MW: 496.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight496.6
XLogP33.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Exact Mass496.22566008
Monoisotopic Mass496.22566008
Topological Polar Surface Area116 Ų
Heavy Atom Count35
Formal Charge0
Complexity811
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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