PROTAC PD-1/PD-L1 degrader-1

• Description:

  PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It restores the suppressed immune response in a co-culture model of Hep3B/OS-8/hPD-L1 cells and CD3 T cells and moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  1076.59

• Molecular Formula:

  C59H58ClN7O11

• Notes:

  Research use only, not for human use.

• Receptor:

  PROTACs | PD-1/PD-L1

• CAS Number:

  2447066-37-5