Tyrphostin 8

• Description:

  Tyrphostin 8 (4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances transferrin receptor-mediated transcytosis in Caco-2 cells, and increases the hypoglycemic effect of oral insulin-transferrin. hypoglycemic effect.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  170.17

• Molecular Formula:

  C10H6N2O

• Notes:

  Research use only, not for human use.

• Receptor:

  GTPase | EGFR | Phosphatase

• CAS Number:

  3785-90-8