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Abt-288

CAT: 1410-M34151-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M34151-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABT-288 is a selective and potent H3 antagonist for the treatment of mild to moderate Alzheimer's dementia.
CAS Number
948845-91-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
372.46
Molecular Formula
C23H24N4O
Notes
Research use only, not for human use.
Receptor
Histamine Receptor

Chemical Information

Abt-288

ABT-288 is under investigation in clinical trial NCT01018875 (Efficacy and Safety Study of ABT-288 in Subjects With Mild-to-Moderate Alzheimer's Disease).

CAS Number948845-91-8
PubChem CID24743471
IUPAC Name2-[4-[4-[(3aR,6aR)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]phenyl]phenyl]pyridazin-3-one
Molecular FormulaC23H24N4O
Molecular Weight372.5
XLogP3
Topological Polar Surface Area39.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity631
SMILES
CN1C[C@H]2CCN([C@H]2C1)C3=CC=C(C=C3)C4=CC=C(C=C4)N5C(=O)C=CC=N5
InChI
InChI=1S/C23H24N4O/c1-25-15-19-12-14-26(22(19)16-25)20-8-4-17(5-9-20)18-6-10-21(11-7-18)27-23(28)3-2-13-24-27/h2-11,13,19,22H,12,14-16H2,1H3/t19-,22+/m1/s1
InChIKey
GNIRITULTPTAQW-KNQAVFIVSA-N
Chemical Structure
2D Structure
2D structure of Abt-288
CAS: 948845-91-8
CID: 24743471
Formula: C23H24N4O
MW: 372.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.5
XLogP33
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass372.19501140
Monoisotopic Mass372.19501140
Topological Polar Surface Area39.2 Ų
Heavy Atom Count28
Formal Charge0
Complexity631
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS5776257ABT-288
5836-FS-025Recombinant Human Follistatin 288 (FS-288)
769-FS-025Recombinant Mouse Follistatin 288 (FS-288)
HY-106457HOE-288
bs-82174C-01BML-288
769-FS-025/CFRecombinant Mouse Follistatin 288 (FS-288) CF
5836-FS-025/CFRecombinant Human Follistatin 288 (FS-288) CF
B7737-50ABT
RM-P190588-01Posaconazole Impurity 288
RM-T140888-01Tenofovir Impurity 288

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