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RMC-4630

CAT: 1410-M28230-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M28230-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RMC-4630 is an inhibitor of SHP2.
CAS Number
2172652-48-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
450.98
Molecular Formula
C20H27ClN6O2S
Notes
Research use only, not for human use.
Receptor
NAChR

Chemical Information

Vociprotafib

Vociprotafib is a small molecule drug. The usage of the INN stem '-protafib' in the name indicates that Vociprotafib is a human protein tyrosine phosphatase (HPTP) inhibitor. Vociprotafib is under investigation in clinical trial NCT05054725 (Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies). Vociprotafib has a monoisotopic molecular weight of 450.16 Da.

CAS Number2172652-48-9
PubChem CID134182831
IUPAC Name[6-[(2-amino-3-chloro-4-pyridinyl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl]methanol
Molecular FormulaC20H27ClN6O2S
Molecular Weight451.0
XLogP1.2
Topological Polar Surface Area149
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity583
SMILES
C[C@H]1[C@H](C2(CCN(CC2)C3=NC(=C(N=C3CO)SC4=C(C(=NC=C4)N)Cl)C)CO1)N
InChI
InChI=1S/C20H27ClN6O2S/c1-11-19(30-14-3-6-24-17(23)15(14)21)26-13(9-28)18(25-11)27-7-4-20(5-8-27)10-29-12(2)16(20)22/h3,6,12,16,28H,4-5,7-10,22H2,1-2H3,(H2,23,24)/t12-,16+/m0/s1
InChIKey
HISJAYUQVHMWTA-BLLLJJGKSA-N
Chemical Structure
2D Structure
2D structure of Vociprotafib
CAS: 2172652-48-9
CID: 134182831
Formula: C20H27ClN6O2S
MW: 451.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight451.0
XLogP31.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass450.1604730
Monoisotopic Mass450.1604730
Topological Polar Surface Area149 Ų
Heavy Atom Count30
Formal Charge0
Complexity583
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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