RMC-4630

CAT: 1410-M28230-04Size: 25 mgDry Ice: NoHazardous: No

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CAT#:1410-M28230-04Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

RMC-4630 is an inhibitor of SHP2.

CAS Number

2172652-48-9

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

450.98

Molecular Formula

C20H27ClN6O2S

Notes

Research use only, not for human use.

Receptor

NAChR

Chemical Information

Vociprotafib

Vociprotafib is a small molecule drug. The usage of the INN stem '-protafib' in the name indicates that Vociprotafib is a human protein tyrosine phosphatase (HPTP) inhibitor. Vociprotafib is under investigation in clinical trial NCT05054725 (Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies). Vociprotafib has a monoisotopic molecular weight of 450.16 Da.

CAS Number	2172652-48-9
PubChem CID	134182831
IUPAC Name	[6-[(2-amino-3-chloro-4-pyridinyl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl]methanol
Molecular Formula	C20H27ClN6O2S
Molecular Weight	451.0
XLogP	1.2
Topological Polar Surface Area	149
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	4
Heavy Atom Count	30
Formal Charge	0
Complexity	583

SMILES

C[C@H]1[C@H](C2(CCN(CC2)C3=NC(=C(N=C3CO)SC4=C(C(=NC=C4)N)Cl)C)CO1)N

InChI

InChI=1S/C20H27ClN6O2S/c1-11-19(30-14-3-6-24-17(23)15(14)21)26-13(9-28)18(25-11)27-7-4-20(5-8-27)10-29-12(2)16(20)22/h3,6,12,16,28H,4-5,7-10,22H2,1-2H3,(H2,23,24)/t12-,16+/m0/s1

InChIKey

HISJAYUQVHMWTA-BLLLJJGKSA-N

Chemical Structure

2D Structure

CAS: 2172652-48-9

CID: 134182831

Formula: C20H27ClN6O2S

MW: 451.0

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	451.0
XLogP3	1.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	4
Exact Mass	450.1604730
Monoisotopic Mass	450.1604730
Topological Polar Surface Area	149 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	583
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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M11296-01	AZD-4635
M12428-01	MI-463
M41249	HBV polymerase (455 - 463)

Alternative Products

Catalog	Name
T39658-01	RMC-4630
T0011015	RMC
BA5764-5	RMC-7977
BA8705-1	RMC-5552
BA5774-1	RMC-0331
BA8077-1	RMC-4550
BA8707-1	RMC-6272
T78212-01	RMC-9805
T75131-01	RMC-6291
T74283-01	RMC-4627

RMC-4630

Chemical Information

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