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BNC105

CAT: 1410-M24994-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1410-M24994-04Size:25 mg
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Description
BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.
CAS Number
945771-74-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
372.37
Molecular Formula
C20H20O7
Notes
Research use only, not for human use.
Receptor
Tubulin polymerization

Chemical Information

Bnc-105

Vascular Disrupting Agent BNC105 is a vascular disrupting agent (VDA), with potential anti-vascular and antineoplastic activities. Upon administration, vascular disrupting agent BNC105 binds to tubulin and inhibits its polymerization, which results in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. This deprives tumor cells of nutrients and results in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization.

CAS Number945771-74-4
PubChem CID24786555
IUPAC Name(7-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone
Molecular FormulaC20H20O7
Molecular Weight372.4
XLogP3.6
Topological Polar Surface Area87.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity499
SMILES
CC1=C(C2=C(O1)C(=C(C=C2)OC)O)C(=O)C3=CC(=C(C(=C3)OC)OC)OC
InChI
InChI=1S/C20H20O7/c1-10-16(12-6-7-13(23-2)18(22)19(12)27-10)17(21)11-8-14(24-3)20(26-5)15(9-11)25-4/h6-9,22H,1-5H3
InChIKey
RADMJHVVIZTENA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bnc-105
CAS: 945771-74-4
CID: 24786555
Formula: C20H20O7
MW: 372.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.4
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass372.12090297
Monoisotopic Mass372.12090297
Topological Polar Surface Area87.4 Ų
Heavy Atom Count27
Formal Charge0
Complexity499
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS3614595-01BNC105
A20945-200BNC105 200mg
A20945-25BNC105 25mg
A20945-5BNC105 5mg
A20945-1BNC105 1mg
A20945-100BNC105 100mg
A20945-50BNC105 50mg
A20945-10BNC105 10mg
A20945-10mM-DBNC105 10mM * 1mL in DMSO

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