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MK-0557

CAT: 1410-M24262-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M24262-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM) .
CAS Number
328232-95-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
406.41
Molecular Formula
C22H18FN4O3
Notes
Research use only, not for human use.
Receptor
Neuropeptide Y (NPY) Y5 receptor

Chemical Information

MK-0557

MK0557 has been investigated for the treatment of Schizophrenia and Paranoid Schizophrenia.

CAS Number328232-95-7
PubChem CID11491176
IUPAC NameN-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
Molecular FormulaC22H19FN4O3
Molecular Weight406.4
XLogP2.6
Topological Polar Surface Area86.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count30
Formal Charge0
Complexity669
SMILES
C1CC2(CCC1C(=O)NC3=NN(C=C3)C4=CC=CC=C4F)C5=C(C=CN=C5)C(=O)O2
InChI
InChI=1S/C22H19FN4O3/c23-17-3-1-2-4-18(17)27-12-8-19(26-27)25-20(28)14-5-9-22(10-6-14)16-13-24-11-7-15(16)21(29)30-22/h1-4,7-8,11-14H,5-6,9-10H2,(H,25,26,28)
InChIKey
RMYZIRFUCOMQRH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MK-0557
CAS: 328232-95-7
CID: 11491176
Formula: C22H19FN4O3
MW: 406.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight406.4
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass406.14411864
Monoisotopic Mass406.14411864
Topological Polar Surface Area86.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity669
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA5621-10MK-0557
FF158573-01MK 0557
A21271-10MK-0557 10mg
A21271-25MK-0557 25mg
A21271-5MK-0557 5mg
A21271-2MK-0557 2mg
A21271-200MK-0557 200mg
A21271-100MK-0557 100mg
A21271-50MK-0557 50mg
A21271-1MK-0557 1mg

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