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AZ7550

CAT: 1410-M23107-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M23107-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
CAS Number
1421373-99-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
485.58
Molecular Formula
C₂₇H₃₁N₇O₂
Notes
Research use only, not for human use.
Receptor
IC50: 1.6 μM (IGF1R), 88 nM (MLK1), 156 nM (ACK1), 195 nM (ErbB4), 228 nM (MNK2)

Chemical Information

N-[4-Methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide
CAS Number1421373-99-0
PubChem CID71496459
IUPAC NameN-[4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]phenyl]prop-2-enamide
Molecular FormulaC27H31N7O2
Molecular Weight485.6
XLogP3.3
Topological Polar Surface Area96.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Heavy Atom Count36
Formal Charge0
Complexity724
SMILES
CNCCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C)OC
InChI
InChI=1S/C27H31N7O2/c1-6-26(35)30-21-15-22(25(36-5)16-24(21)33(3)14-13-28-2)32-27-29-12-11-20(31-27)19-17-34(4)23-10-8-7-9-18(19)23/h6-12,15-17,28H,1,13-14H2,2-5H3,(H,30,35)(H,29,31,32)
InChIKey
ZROCWKZRGJYPTG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[4-Methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide
CAS: 1421373-99-0
CID: 71496459
Formula: C27H31N7O2
MW: 485.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight485.6
XLogP33.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Exact Mass485.25392326
Monoisotopic Mass485.25392326
Topological Polar Surface Area96.3 Ų
Heavy Atom Count36
Formal Charge0
Complexity724
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BUP01438-01AZ7550
A12008-1AZ7550 1mg
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HY-B0794S-01AZ7550-d5
JSD76240-01Az7550 hydrochloride
A12008-50AZ7550 50mg
HY-B0794A-01AZ7550 (hydrochloride)
A12008-100AZ7550 100mg

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