UT-34

CAT: 1410-M22452-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No

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CAT#:1410-M22452-02Size:1 mL x 10 mM in DMSO

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader (IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prostate cancer efficacy. In LNCaP cells, UT-34 (3-10 µM; 24 hours) treatment inhibits the expression of PSA and FKBP5 and growth of LNCaP cells starting from 100 nM with maximum effect observed at 10 μM.

CAS Number

2168525-92-4

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

356.27

Molecular Formula

C15H12F4N4O2

Notes

Research use only, not for human use.

Receptor

Androgen receptor

Chemical Information

(S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-fluoro-1H-pyrazol-1-yl)-2-hydroxy-2-methylpropanamide

CAS Number	2168525-92-4
PubChem CID	132214622
IUPAC Name	(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluoropyrazol-1-yl)-2-hydroxy-2-methylpropanamide
Molecular Formula	C15H12F4N4O2
Molecular Weight	356.27
XLogP	1.3
Topological Polar Surface Area	90.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Heavy Atom Count	25
Formal Charge	0
Complexity	549

SMILES

C[C@](CN1C=C(C=N1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O

InChI

InChI=1S/C15H12F4N4O2/c1-14(25,8-23-7-10(16)6-21-23)13(24)22-11-3-2-9(5-20)12(4-11)15(17,18)19/h2-4,6-7,25H,8H2,1H3,(H,22,24)/t14-/m0/s1

InChIKey

YDRMSDHDYRAUBR-AWEZNQCLSA-N

Chemical Structure

2D Structure

CAS: 2168525-92-4

CID: 132214622

Formula: C15H12F4N4O2

MW: 356.27

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	356.27
XLogP3	1.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	356.08963829
Monoisotopic Mass	356.08963829
Topological Polar Surface Area	90.9 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	549
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BA9176-5	UT-34
BA9182-5.1	UT-155
GTR19220933-01	UT-11
GTR19236641	UT-59

UT-34

Chemical Information

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