UT-34

• Description:

  UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader (IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prostate cancer efficacy. In LNCaP cells, UT-34 (3-10 µM; 24 hours) treatment inhibits the expression of PSA and FKBP5 and growth of LNCaP cells starting from 100 nM with maximum effect observed at 10 μM.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  356.27

• Molecular Formula:

  C15H12F4N4O2

• Notes:

  Research use only, not for human use.

• Receptor:

  Androgen receptor

• CAS Number:

  2168525-92-4